Polynucleotides

Polynucleotides are next-generation biostimulators that work at a cellular level to improve skin quality. Often derived from fish DNA, they help activate fibroblasts, encouraging your own collagen and elastin production while modulating inflammation—leading to firmer, smoother, healthier-looking skin over time.

Best suited for

  • Under-eye darkness/crepiness and fragile skin

  • Fine lines, laxity and loss of elasticity (face, neck, hands)

  • Uneven texture, mild acne scarring and post-inflammatory marks

  • Dullness or “tired” skin that is lacking glow


How polynucleotides work

Rather than adding volume, polynucleotides support the skin’s micro-environment: they activate fibroblasts, promote tissue repair and improve dermal hydration balance. Results are progressive, session by session, with natural-looking improvements in texture, elasticity and luminosity.


At a glance

  • Procedure time: 20–30 minutes

  • Course: Usually 2–4 sessions, 2–4 weeks apart

  • Onset: Gradual; improvements build across the course, consolidating over 8–12 weeks

  • Longevity: Maintain with top-ups every 6–12 months (individual variation)

  • Downtime: Mild redness/swelling or small pin-pricks for 24–48 hours (occasionally mild bruising)

Aftercare (quick guide)

  • Keep areas clean and dry on the day; avoid makeup for 24 hours.

  • No strenuous exercise, alcohol, hot baths/saunas for 24 hours.

  • Avoid active skincare (retinoids/acids) for 3–5 days on treated zones.

  • Daily SPF 50+ helps protect and prolong results.

Treatment areas

  • Face (including the delicate under-eye area)

  • Neck, décolletage and hands.

  • Selected scarring and stretch-mark sites (case by case)

We’ll tailor placement and session count to your skin and goals.


Extended indications

Hair loss support (scalp)

Polynucleotides can help create a healthier scalp environment—supporting follicle function, modulating inflammation and improving tissue quality. Many patients notice reduced shedding, better strand thickness and improved scalp comfort over a course.
Synergy: Often paired with PRF for enhanced outcomes.

Scars & hyperpigmentation

By encouraging tissue regeneration and calming chronic inflammation, polynucleotides can soften the look of acne scars and help even out post-inflammatory colour irregularity in suitable cases.


Your treatment journey

  1. Medical consultation: Skin/scalp assessment, history and goal setting.

  2. Personalised plan: Areas, session count and sequencing (e.g., with PRF or skin boosters).

  3. Treatment: Gentle micro-injections for even coverage; anaesthetic cream can be used if needed.

  4. Review & maintenance: Progress check and maintenance timings to sustain results.

Ready to rejuvenate from within?

Book a £30 consultation (credited against treatment) to design a polynucleotide plan—on its own or combined with PRF/skin boosters—tailored to your goals.

Frequently Asked Questions

They’re biostimulators that activate fibroblasts, increasing collagen/elastin production, skin quality and resilience over time.

 

 

 

No. They don’t add volume (like fillers) or primarily hydrate (like boosters); they remodel the skin’s micro-environment.

 

Typically 2–4 sessions, 2–4 weeks apart, then maintenance every 6–12 months.

 

 

Improvements are gradual—most notice changes from 6–8 weeks, with best results 3–4 months after the course.

 

 

Available Treatments

Evidence-based options chosen for safety, efficacy, and natural-looking outcomes. 

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